Molecular Mechanisms of Synaptic Plasticity
I aim to mechanistically understand how assemblies of synaptic proteins contribute to synaptic plasticity in health and disease
Team Leader Guus Smit
Team Leader Sabine Spijker
Animal Models of Psychiatric Disease
The focus of my team is on cognition and how it is affected by neuropsychiatric ailments, such as depression, addiction, and impulsivity. We study maladaptation of synapses and circuitry brought about by unique molecular signatures in hippocampus and prefrontal cortex.
Team Leader Ronald van Kesteren
Brain Plasticity in Health and Disease
My research focusses on molecular, cellular and network mechanisms of neuronal and synaptic plasticity in normal brain function and in situations of impaired or altered plasticity, such as healthy aging, Alzheimer’s disease, schizophrenia and neuronal injury.
Team Leader Mark Verheijen
Glial Regulated Neuronal Plasticity
Our research aims to discover new glial-based mechanisms of information processing in the brain in health and disease, with a focus on the role of astrocytes in the regulation of myelin and synaptic plasticity.
Team Leader Michel van den Oever
Memory Circuits
The objective of my team is to gain detailed insight in the neural circuitry that mediates the formation and retrieval of stable, long-lasting associative memories
Team Leader Ka Wan Li
Neuroproteomics
My Neuroproteomics team aims to (1) describe the protein complex nano-machinery that underlies synapse function and plasticity, and (2) reveal the alteration of synapse/tissue proteomes in cases of neuro-degenerative and neuropsychiatric disorders. Mass spectrometry based quantitative proteomics analysis is the leading technology behind these studies.
Team Leader Taco de Vries
Addiction
My aim is to unravel the neurobiological mechanisms underlying drug addiction with a particular focus on relapse mechanisms related to alcohol and nicotine. These studies have a strong multidisciplinary character and include behavioural analysis, proteomics, neurophysiology and opto- and chemogenetic approaches.
Team Leader Joost Verhaagen
Axon Regeneration
The overall objective of the Laboratory for Neuroregeneration is to unravel the biological mechanisms that govern successful regeneration in the PNS and that underlie degeneration and regenerative failure in the CNS. The primary long-term research objective is to make significant contributions to the field of restorative neuroscience and neurology.