We study dementias, such as Alzheimer’s disease and frontal temporal lobe dementia (FTD)
• We use various mouse models. A major aim in this research is to understand aspects of aberrantly adapted synaptic and circuitry function. To achieve this we integrate molecular, cellular and behavioural approaches and try to reach a systems level description.
• Interventions using opto- and chemo-genetic approaches (Ronald van Kesteren, Michel) are necessary technologies to obtain causal understanding of mechanisms that act at the circuitry level and extent all the way up to behavior.
• We use cellular models (link cellomics). Recently, the use of iPSC-derived human neurons was introduced as these may represent cellular dysfunction in the specific genomic context of the patient.
• When possible we use postmortem human brain tissue to translate our findings obtained in models to conditions in the human brain (Guus Smit).