A collaborative study by members of the Memory Circuits team together with the lab of Harm Krugers and Sylvie Lesuis (UvA) reveals that elevated levels of the stress hormone corticosterone induce an increase in the size of a hippocampal fear engram and this change underlies generalized expression of fear in a neutral environment. Their findings were published in Biological Psychiatry.

A new study by David Hondius, Frank Koopmans and colleagues provides molecular evidence that so-called granulovacuolar cells are representing the pre-tangle neuronal stage in Alzheimer disease. The study was published in Acta Neuropathologica on January 25, 2021.