Michel van den Oever and Esther Visser were involved in a study on compulsive alcohol use led by Markus Heilig and Esi Domi at the Linköping University in Sweden. Using the viral-TRAP technique developed by the CNCR Memory Circuits team, they identified a small population of PKC-delta-expressing neurons in the central amygdala that drives footshock-punished alcohol intake. Their findings are published in Science Advances.

A collaborative study by members of the Memory Circuits team together with the lab of Harm Krugers and Sylvie Lesuis (UvA) reveals that elevated levels of the stress hormone corticosterone induce an increase in the size of a hippocampal fear engram and this change underlies generalized expression of fear in a neutral environment. Their findings were published in Biological Psychiatry.

A new study by David Hondius, Frank Koopmans and colleagues provides molecular evidence that so-called granulovacuolar cells are representing the pre-tangle neuronal stage in Alzheimer disease. The study was published in Acta Neuropathologica on January 25, 2021.

Memory Circuits Team (Michel van den Oever) and Alzheimer Team (Ronald van Kesteren) join forces to test how hyperactive interneurons affect the formation and reactivation of memory engrams. They receive a 300 k€ grant from Alzheimer Nederland to investigate this.

PhD student Esther Visser and colleagues in the team of Michel van den Oever (MCN) investigated how alcohol memories are stored in the brain and how this contributes to relapse after prolonged abstinence. Their findings were published in Science Advances.

A new study by Miguel Gonzalez-Lozano (MCN) and colleagues demonstrates how cross-linking mass spectrometry can contribute to the discovery of novel synaptic protein interactions. The study was published in Science Advances on February 19, 2020.

A new study by PhD student Sara Hijazi (MCN) shows that reducing the activity of interneurons in the hippocampus restores memory and delays Alzheimer’s disease progression in mice. The study is published in Molecular Psychiatry.

A new study by PhD student Martina Rosato (MCN) shows that combined cellular and molecular profiling is able to reveal novel biological insight into the polygenic nature of schizophrenia. The study was published last month in Molecular Psychiatry.

A study performed by PhD students Mariana Matos and Esther Visser in the team of Michel van den Oever reveals that expression of a remote fear memory depends on a small ensemble of neurons in the medial prefrontal that functions as an enduring physical memory trace, or engram.

A team of researchers from the CNCR (led by Priyanka Rao-Ruiz and Michel van den Oever, MCN lab) and the Erasmus MC (led by Steven Kushner, Dept. of Psychiatry) used a sensitive and unbiased RNA sequencing approach to identify gene expression signatures critical to the storage of long-term memories by sparse ensembles of hippocampal neurons. This collaborative effort was published in Nature Communications.